The high sensitivity of the QCM sensor is combined with selectivity of receptor–ligand interactions to construct a biosensor which would discriminate breast cancer cells with high metastatic power from those of low or no metastatic potential to develop a simple, fast and efficient system to be used in breast cancer diagnosis.
…Read MoreProstate specific antigen (PSA) is an important biomarker for diagnosis and prognosis of prostate can- cer. Herein, microcontact PSA-imprinted surface plasmon resonance (SPR) sensor chip was developed for sensitive, real-time detection of PSA. The imprinted chip was prepared in the presence of methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker via UV poly- merization using microcontact imprinting technique. PSA imprinted SPR sensor chip was characterized by atomic force microscope (AFM), scanning electron microscope (SEM), ellipsometry, dispersive Raman and Fourier transform infrared spectroscopy (FT-IR).
…Read MoreHacettepe Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı Başkanı Prof. Dr. Gökhan Özyiğit tarafından 12 Kasım 2014 tarihinde Altındağ Belediyesi Gençlik Merkezi’nde verilen konferans ile başlayan “Bilim ve Teknik Dergisi Bilim Söyleşileri” sürüyor.
…Read MoreTrietazine was selectively separated from aqueous solution containing the competitor molecule cyanazine, which is similar in size and shape to the template molecule. Structural features of the molecularly imprinted column were figured out by SEM. The influence of the mobile-phase composition, applied electrical field, and pH of the mobile phase on the recognition of trietazine by the imprinted monolithic polymer has been evaluated, and the imprint effect in the trietazine-imprinted monolithic polymer was demonstrated by an imprinting factor.
…Read MoreHighlights of this paper...
Introduction to this paper... Most chemical and biochemical reactions are catalyzed by natural enzymes with a high degree of specificity and reaction rates under mild conditions (1). Therefore, the creation of artificial catalysts that can provide the catalytic properties of natural enzymes has attracted scientists’ attention. Many attempts to develop enzyme mimics involved the use of host–guest chemistry such as supramolecular complexes (2), cyclodextrins (3), cryptands (4), and crown ethers (5). In addition, functionalized polymers (6), vesicles and micelles (7), artificial polypeptides (8, 9), and catalytic antibodies (10, 11) have been used in this field. Molecularly imprinted polymers (MIPs) are other promising materials in the construction of enzyme mimics (12–15).
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